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What is Starlix?

Starlix (nateglinide) is an oral drug used to lower blood sugar (glucose) levels in type 2 diabetes (non-insulin-dependent diabetes mellitus) in patients who do not have enough diet and exercise to control the glycemic level and who have not been treated for a long time by other hypoglycemic agents. Nateglinide is also indicated for therapy in combination with metformin in patients with inadequate control of the level of glycemia against metformin (it is not recommended to replace metformin with nateglinide).

How should I use Starlix?

Starlix should be taken orally before meals. The time interval between taking the drug and eating should not exceed 30 minutes. As a rule, the drug is taken immediately before meals.

When using Starlix as monotherapy, the recommended dose is 120 mg 3 times a day (before breakfast, lunch and dinner). If this dosage regimen fails to achieve the desired effect, the single dose can be increased to 180 mg.

Combination therapy. In some cases, Starlix can be combined with metformin therapy. Conversely, patients who are already receiving metformin therapy may be prescribed Starlix in a dose of 120 mg 3 times a day (before meals) as an additional agent.

What are the contraindications of this medicine?

Do not take Starlix if you have any of the following conditions:

  • hypersensitivity to the active substance or any of the components of the drug;
  • type 1 diabetes;
  • diabetic ketoacidosis;
  • pregnancy, breastfeeding period;
  • age up to 18 years (due to the lack of data from clinical studies for this age group of patients);
  • abnormal liver functions (due to the lack of data of clinical trials for this population of patients).

With caution: elderly patients, reduced nutrition, adrenal or pituitary insufficiency, severe renal impairment.

What are the side effects of Starlix?

  • Nervous system and sensory organs: dizziness;
  • Respiratory system disorders: upper respiratory tract infections, bronchitis, cough;
  • Digestive tract: diarrhea;
  • Metabolism: hypoglycemia;
  • Musculoskeletal system: arthropathy, accidental injury;
  • Other: spinal pain, flu-like symptoms

What may interact with this medicine?

It’s not recommended to combine Starlix with any of the drugs listed below:

  • tolbutamide;
  • beta blockers;
  • NSAIDs (including salicylates);
  • MAO inhibitors;
  • non-selective beta-blockers and hypoglycemic drugs;
  • thiazide diuretics;
  • GCS;
  • adrenergic stimulants;
  • thyroid drugs

What should I watch for while using this medicine?

Nateglinide had no teratogenic effect in experimental studies. The experience of using Starlix during pregnancy is currently not available, so the safety of the drug for pregnant women has not been established. Do not use the drug during pregnancy.

Nateglinide is excreted in breast milk in rats. It is not known whether the drug is excreted in breast milk in women, so due to the potential risk of hypoglycemia in breastfed infants, these tablets should not be given to breastfeeding women.

Cases of overdose have not yet been described. Possible symptoms: severe hypoglycemia with clinical manifestations of varying severity.

Patients working with machinery and driving vehicles should take special precautions to prevent hypoglycemia.

When using this medication, care should be taken regarding the occurrence of hypoglycemia. The decrease in glucose concentration in the blood can be triggered by alcohol intake and increased physical exertion.

To assess the therapeutic efficacy of the drug, you can also use the indicator of the concentration of glucose in the blood 1-2 hours after a meal.

Starlix can be used both as monotherapy and in combination with hypoglycemic drugs with a different mechanism of action, for example, metformin.